Research Interests and Publications
Dr. Wehr studies how local circuits in the cerebral cortex encode and transform sensory information. His laboratory uses mouse auditory cortex as a model system to investigate how cellular and network properties shape cortical responses to a continuous and temporally complex stream of sensory data. Research in his lab combines aspects of both cellular, systems, and theoretical neuroscience, by using the tools of molecular biology and cellular physiology to address systems-level questions. By using a variety of methods including optogenetics, in vivo whole-cell and single-unit electrophysiology, quantitative behavior, and imaging, the laboratory is trying to identify the cellular and synaptic mechanisms with which cortical circuits process auditory information, leading ultimately to our perceptual experiences of acoustic streams, such as music and speech.
To learn more about current research, and to download publications, please visit http://www.uoneuro.uoregon.edu/wehr/
Weible, A., Stebritz, A., Wehr, M. (2020). 5XFAD mice show early onset gap encoding deficits in auditory cortex. Neurobiology of Aging (in press).
Weible, A., Yavorska, I., Wehr, M. (2020). A cortico-collicular amplification mechanism for gap detection. Cerebral Cortex Feb 14; doi.org/10.1093/cercor/hbz328.
O'Sullvan, C., Weible, A., Wehr, M. (2020.) Disruption of early or late epochs of auditory cortical activity impairs speech discrimination in mice. Frontiers in Neuroscience Jan 10; doi.org/10.3389/fnins.2019.01394.
O'Sullivan, C., Weible, A., and Wehr, M. (2019). Auditory cortex contributes to discrimination of pure tones. eNeuro, Oct 7; doi.org/10.1523/eneuro.0340-19.2019.
Kaylegian, K., Stebritz, A., Weible, A., Wehr, M. (2019). 5XFAD Mice show early onset gap detection deficits. Frontiers in Neuroscience, April 2; doi.org/10.3389/fnagi.2019.00066.
Saunders, J., Wehr, M. (2019). Mice can learn phonetic categories. JASA, March 145 (3), doi.org/10.1121/1.5091776.
Moore, A., Weible, A., Balmer, T., Trussel, L., and Wehr, M. (2018). Rapid rebalancing of excitation and inhibition by cortical circuitry. Neuron, Mar 21;97(6):1341-1355.
Keller, C., Kaylegian, K., and Wehr, M. (2018). Gap encoding by parvalbumin-expressing interneurons in auditory cortex. J Neurophysiol. Mar 28.
Yavorska, I., Wehr, M. (2016). Somatostatin-Expressing Inhibitory Interneurons in Cortical Circuits. Frontiers in Neural Circuits. Sept 29;10:76.
Hoy, J.L., Yavorska, I., Wehr, M., Niell, C.M. (2016). Vision Drives Accurate Approach Behavior during Prey Capture in Laboratory Mice. Curr Biology Nov21;26(22):3046-3052.
Gao, X., and Wehr, M. (2015). A coding transformation for temporally structured sounds within auditory cortical neurons. Neuron, Mar 25.