Research Interests and Publications
Dr. Wehr studies how local circuits in the cerebral cortex encode and transform sensory information. His laboratory uses mouse auditory cortex as a model system to investigate how cellular and network properties shape cortical responses to a continuous and temporally complex stream of sensory data. Research in his lab combines aspects of both cellular, systems, and computational neuroscience, by using the tools of molecular biology and cellular physiology to address systems-level questions. By using a variety of methods including optogenetics, in vivo whole-cell and single-unit electrophysiology, behavior, and imaging, the laboratory is trying to identify the cellular and synaptic mechanisms with which cortical circuits process auditory information, leading ultimately to our perceptual experiences of acoustic streams, such as music and speech.
To learn more about current research, and to download publications, please visit http://www.neuro.uoregon.edu/wehr/
Gao, X., and Wehr, M. (2015). A coding transformation for temporally structured sounds within auditory cortical neurons. Neuron, in press.
Weible, AP., Liu, C., Niell, CM., Wehr, M. (2014). Auditory cortex is required for fear potentiation of gap detection. J Neurosci. Nov 12;34(46):15437-45.
Kyweriga, M., Stewart, W., Cahill, C., and Wehr, M. (2014). Synaptic mechanisms underlying interaural level difference selectivity in rat auditory cortex. J Neurophysiol. 15;112(10):2561-71.
Weible, A., Moore, A., Liu, C., deBlander, L., Wu, H., Kentros, C., and Wehr, M. (2014). Perceptual Gap Detection is Mediated by Gap Termination Responses in Auditory Cortex. Current Biology 24(13):1447-55.
Moore, A., and Wehr, M. (2014). A guide to in vivo single-unit recording from optogenetically identified cortical inhibitory interneurons. J. Vis. Exp. (93), e51757.
Kyweriga, M., Stewart, W., and Wehr, M. (2014). Neuronal interaural level difference response shifts are level-dependent in the rat auditory cortex. J. Neurophysiol. 111(5):930-8.
Moore, A., and Wehr, M. (2013). Parvalbumin-expressing inhibitory interneurons in auditory cortex are well-tuned for frequency. J Neurosci 33(34):13713-23.